Both globin genes are present in the cell, but fail to produce hemoglobin adequately (This contrasts with alpha thalassemia, below, in which one or more of the genes is actually missing from the cell). Abstract Thalassemia’s are genetic disorders inherited from a person’s parents. There is nothing that a mother or father does (or does not do) to direct which chromosome, and therefore which allele, is transmitted to his or her children. In all countries thalassemia screening has contributed for reduced incidence of beta thalassemia and carrier screening is an essential intervention in all these preventive programs [5,6,9]. People who are carriers of thalassaemia are also at risk of having a child with a blood disorder if their partner is a carrier of a different type of blood disorder. Thalassemia and sickle cell mutations confer resistance to malaria, and high prevalence of the both gene defects are found in the same areas due to the advantage of heterozygosity. If a person received an alpha thalassemia trait from her mother and the normal alpha parts from her father, she would have alpha thalassemia trait (also called alpha thalassemia minor). Recessive Inheritance. ... a benign trait or carrier state can exist in which an individual has both a normal and a mutated copy of the gene. The Inheritance of Thalassemia. Carriers of alpha and beta thalassemia traits, get married or not? It doesn't work in this way directly in this way, you need to only consider the parents of the kid (and in case you transport thalassemia you should really check before getting pregnant, really). It is inherited, that is, it is passed on from […] You can find more detailed information about some of the other types of carrier in the following leaflets: Haemoglobin O Arab carrier (PDF, 831kb) Haemoglobin C carrier (PDF, 396kb) Thalassaemia is a characteristic of the blood.
Thalassemia Minor is inherited if the abnormal gene comes from only one parent, i.e the mother or the Father.

If the sperm is normal, the child will be a healthy carrier of thalassemia. the only thing to know is t6hat if both husband and wife are Thalassemia carrier then in each pregnancy there is 25% chance of having a thalassemia major child, 50% chance of having Thalassemia minor/carrier child and 25% "Normal-not even a carrier" Dr J.S.


P People originating from the Mediterranean, the Middle East, Africa or Asia may carry some form of thalassaemia but it’s rare in Northern Europeans. In India there are many cases in which a thalassemia major is married to a normal … Thalassaemia is common in these regions because it helps to protect carriers against malaria. For instance, if a person receives a beta thalassemia trait from his father and another from his mother, he will have beta thalassemia major. ⦁ Thalassemia Major with Normal Person: – If a thalassemia major patient marries a normal person then, in each pregnancy there is 100 % possibility of the child to carry thalassemia minor trait. Beta Thalassemia A defect in the production of beta globin protein from the beta genes is the most common cause of beta thalassemia. If the Normal egg meets a thalassemic sperm, the child will bbe a healthy carrier. RESULTS: Laboratory investigations for alkaline electrophoresis of blood lysate on cellulose acetate membrane showed raised hemoglobin A 2 level in mother (Hb A 2 = 5.3%), in three daughters (Hb A 2 =6.5, 5.9, 5.5% in chronological and birth order), in two twin sons (Hb A 2 =5.9% and 6.0%) and normal (Hb A 2 = 3.3%) for father. Arora General Secretary National Thalassemia Welfare Society & But if the mother produces a thalassemic egg, it matters very much what kind of sperm meets it. A couple seeking premarital genetic counseling: Male: heterozygous for ∆3.7 single gene deletion mutation (alpha thalassemia trait) If the normal egg meets a normal sperm, the child will be completely normal. It is surprising that Bam, with the highest incidence rate of α thal and β thal carriers , was not among the high frequent sickle cell carrier regions.