Mantle cell lymphoma with leukemic presentation is uncommon and is often difficult to distinguish from other chronic lymphoproliferative disorders. Circulating lymphoma cells detected either by morphology or by FC may be a manifestation of the biology of this disease rather than a poor prognostic indicator. This heterogeneous course is related, in part, to the different biological characteristics of conventional MCL (cMCL) and the distinct subgroup of leukemic nonnodal MCL (nnMCL). Virchows Arch 2000; 437 : 591–598.

Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy, but some patients have a very indolent evolution. Mantle cell lymphoma (MCL) ... and no differences were observed between patients with overt leukemic MCL and the group without morphologic evidence of leukemic involvement. And you see people with leukemic, non-nodal mantle cell lymphoma eventually develop big lymph nodes everywhere." Mantle Cell lymphoma is typically an aggressive, rare, form of non-Hodgkin lymphoma (NHL) that arises from cells originating in the “mantle zone.” MCL accounts for roughly six percent of all NHL cases in the United States. Often, indolent cases of … Eight patients died at a mean of 13 months, and only 1 patient was disease free. Mantle cell lymphoma in leukemic phase showed a very aggressive clinical course. Mantle cell lymphoma, in leukemic phase with prominent splenomegaly. About Lymphoma > Leukemic Phase. Chieh Lin Fu, Maria Julia Diacovo; Niemann-Pick disease with isolated leukemic nonnodal mantle cell lymphoma of the spleen, Blood, Volume 135, Issue 10, 5 Marc A report of eight cases with similar clinical presentation and aggressive outcome. Last update: 03/13/2014 TOPIC SEARCH: PubMed A "leukemic or blastoid phase" is a finding of unusual high amounts of lymphocytes in the peripheral blood (lymphocytosis) suggesting that the lymphoma cells are in the blood in high concentrations.lymphocytosis is an abnormal increase in the number of lymphocytes — a type of white blood cell …