Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 and HBA2. Alpha thalassemia occurs when one or more of the genes that control the making of alpha globins is absent or defective. Alpha Thalassemia: thalassemia occurs if there are problems with some or all of the alpha-globin genes. ; There are four types of alpha thalassemia, hemoglobin Bart hydrops fetalis syndrome or Hb Bart syndrome (the more severe form), HbH disease, … *Alpha thalassemia facts medical author: Melissa Conrad Stöppler, MD. Thalassaemia is usually diagnosed within the first six months of life and can be fatal in early childhood without ongoing treatment. There are four main types of Alpha Thalassemia disease: Treatment is the key to living longer and better. Beta-thalassaemia involves changes in one gene (HBB). Alpha-thalassaemia is a group of disorders of haemoglobin synthesis, caused by mutations or deletions in at least 1 of the 4 alpha-globin genes, leading to variably impaired alpha-globin chain production, with accumulation of the now excess and unpaired beta-globin chains.

Alpha-thalassemia is a blood disorder that reduces the body's production of hemoglobin.Affected people have anemia, which can cause pale skin, weakness, fatigue, and more serious complications.Two types of alpha-thalassemia can cause health problems: the more severe type is known as Hb Bart syndrome; the milder form is called HbH disease.. Hb Bart syndrome may be … There are also steps you can take to stay as healthy as possible. alpha thalassemia, which include the subtypes hemoglobin H and hydrops fetalis; thalassemia minor; All of these types and subtypes vary in symptoms and severity. Inherit 2 mutated genes, signs and symptoms of thalassemia will be mild. Causes. Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood. Normally, each person has four genes for alpha globin. Thalassemia is genetic. Alpha-thalassaemia involves genetic changes in two genes (HBA1 and HBA2). There are two different types of thalassaemia: alpha (a) and beta (b). Alpha thalassemia is a blood disorder that reduces the production of normal hemoglobin, the protein in red blood cells that carries oxygen to cells throughout the body.